commercial ultrasound imaging system vantage 256  (Verasonics Inc)

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: Electrical impedance measurements of the corresponding element of the snCMUT: the phase part ( a ) and the amplitude part ( b ). The electrical impedance was measured using different bias voltages, 10 to 50 V of DC. Phase shifts with bias voltage were observed. The resonant frequency in air was 6.7 MHz at 50 V of bias. c The dynamic plate displacement of the snCMUT measuring from a laser Doppler vibrometer. The maximum displacement was measured in the four-piston top plate’s positive (left) and negative (right) direction. d The maximum peak-to-peak displacement of the four-piston top plate. e Comparison of the displacement profile of the moving top plate between conventional CMUT and snCMUT. The measured displacement profile is from the red dashed line in ( d ). The bias voltage of each CMUT is 48% of the pull-in voltage. Even though there are variations in the maximum displacement of each piston top plate, the embedded silicon nanocolumn induces parallel motion of the top plate in CMUT, which causes enhanced average displacement. f Measured acoustic pressure of the snCMUT via hydrophone as follows a number of operating elements at a distance of 3.5 mm in corn oil. g Impulse response (16.6 ns, 20V PP ) and its Fourier transform of a snCMUT array element under dc bias of 50 V measured by hydrophone in corn oil. h 39 dB amplified pulse-echo impulse response (16.6 ns, 20 V PP ) and its Fourier transform of a snCMUT array element under DC bias of 50 V reflected on ultrasound gel pad and air interface.

Article Snippet: The FPCB was designed to include connectors for a commercial ultrasound imaging system (Vantage 256 research ultrasound system; Verasonics Inc., USA).

Techniques: Comparison, Amplification, Ultrasound Gel

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: The optical photograph of the conventional CMUT probe ( a ) and the disposable snCMUT patch ( b ) on the top surface of the commercial phantom with ultrasound gel. The blue and red boxes indicate the visible area of the phantom by conventional CMUT and disposable snCMUT patches, respectively. c B-mode images of the conventional CMUT probe in the vertical group and anechoic target of the commercial phantom. The conventional CMUT was operated with a DC bias voltage of 70 V, complemented by 30.6 V PP and 6.25 MHz of AC wave. B-mode images of the disposable snCMUT patch in the vertical group and anechoic target ( d ) and the axial-lateral resolution array ( e ) of the commercial phantom. The snCMUT was operated with a DC bias voltage of 40 V, complemented by 8.9 V PP and 4.25 MHz of AC wave. f , Intensity of vertical group targets as a function of the imaging depth of conventional CMUT and snCMUT. All values are expressed in a.u., which denotes arbitrary units. Axial ( g ) and lateral ( h ) resolutions of the vertical group targets along the imaging depth compared between PZT-based commercial ultrasound probe, conventional CMUT, and snCMUT. Data are presented as means ± standard deviation ( n = 4 independent experiments). i Contrast of B-mode images as a function of the imaging depth of conventional CMUT and snCMUT. Compared to the conventional CMUT probe, the disposable snCMUT patch offers enhanced contrast and the ability to image deeper regions, thanks to its high transmission efficiency. Data are presented as means ± standard deviation ( n = 4 independent experiments). All values are expressed in a.u., which denotes arbitrary units.

Article Snippet: The FPCB was designed to include connectors for a commercial ultrasound imaging system (Vantage 256 research ultrasound system; Verasonics Inc., USA).

Techniques: Ultrasound Gel, Imaging, Standard Deviation, Transmission Assay

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: a Photograph of attached disposable snCMUT patches onto both sides of the human neck for real-time ultrasound imaging and blood pressure monitoring of human carotid arteries. The B-mode images at the human neck surface aligned with vertical cross-sections of the common carotid artery (CCA) on the right ( b ) and left ( c ) side of the neck. The enhanced transmission efficiency provided clear ultrasound images, enabling the distinction of not only the CCA but also the internal jugular vein (JV) and sternocleidomastoid muscle (SCM). d The B-mode image of left neck side transverse CCA for monitoring carotid artery pulsations from detecting wall. The applied DC bias voltage was 30 V supplemented by 24.5 V PP of 4.25 MHz AC wave for ultrasound imaging via disposable snCMUT patches. e M-mode image of the pulsation pattern of CCA walls. f The waveforms of blood pressure derived from carotid vessel diameters of the M-mode image ( e ) as a function of time. Physiological parameters from the arterial pulse waveforms, including the heart rate and blood pressure, were derived. g Systolic blood pressure on the left and right side of the neck of 9 healthy volunteers simultaneously monitored by two disposable snCMUT patches. Data are presented as means ± standard deviation ( n = 5 independent experiments).

Article Snippet: The FPCB was designed to include connectors for a commercial ultrasound imaging system (Vantage 256 research ultrasound system; Verasonics Inc., USA).

Techniques: Imaging, Transmission Assay, Derivative Assay, Standard Deviation

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: Electrical impedance measurements of the corresponding element of the snCMUT: the phase part ( a ) and the amplitude part ( b ). The electrical impedance was measured using different bias voltages, 10 to 50 V of DC. Phase shifts with bias voltage were observed. The resonant frequency in air was 6.7 MHz at 50 V of bias. c The dynamic plate displacement of the snCMUT measuring from a laser Doppler vibrometer. The maximum displacement was measured in the four-piston top plate’s positive (left) and negative (right) direction. d The maximum peak-to-peak displacement of the four-piston top plate. e Comparison of the displacement profile of the moving top plate between conventional CMUT and snCMUT. The measured displacement profile is from the red dashed line in ( d ). The bias voltage of each CMUT is 48% of the pull-in voltage. Even though there are variations in the maximum displacement of each piston top plate, the embedded silicon nanocolumn induces parallel motion of the top plate in CMUT, which causes enhanced average displacement. f Measured acoustic pressure of the snCMUT via hydrophone as follows a number of operating elements at a distance of 3.5 mm in corn oil. g Impulse response (16.6 ns, 20V PP ) and its Fourier transform of a snCMUT array element under dc bias of 50 V measured by hydrophone in corn oil. h 39 dB amplified pulse-echo impulse response (16.6 ns, 20 V PP ) and its Fourier transform of a snCMUT array element under DC bias of 50 V reflected on ultrasound gel pad and air interface.

Article Snippet: Transducers were vertically placed on the surface of the phantom using ultrasound gel and operated using a commercial ultrasound imaging system (Vantage 256 system, Verasonics, Inc.) to scan over the phantom and reconstruct the imaging planes by employing a plane-wave compounding method, custom-programmed by MATLAB (MathWorks).

Techniques: Comparison, Amplification, Ultrasound Gel

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: The optical photograph of the conventional CMUT probe ( a ) and the disposable snCMUT patch ( b ) on the top surface of the commercial phantom with ultrasound gel. The blue and red boxes indicate the visible area of the phantom by conventional CMUT and disposable snCMUT patches, respectively. c B-mode images of the conventional CMUT probe in the vertical group and anechoic target of the commercial phantom. The conventional CMUT was operated with a DC bias voltage of 70 V, complemented by 30.6 V PP and 6.25 MHz of AC wave. B-mode images of the disposable snCMUT patch in the vertical group and anechoic target ( d ) and the axial-lateral resolution array ( e ) of the commercial phantom. The snCMUT was operated with a DC bias voltage of 40 V, complemented by 8.9 V PP and 4.25 MHz of AC wave. f , Intensity of vertical group targets as a function of the imaging depth of conventional CMUT and snCMUT. All values are expressed in a.u., which denotes arbitrary units. Axial ( g ) and lateral ( h ) resolutions of the vertical group targets along the imaging depth compared between PZT-based commercial ultrasound probe, conventional CMUT, and snCMUT. Data are presented as means ± standard deviation ( n = 4 independent experiments). i Contrast of B-mode images as a function of the imaging depth of conventional CMUT and snCMUT. Compared to the conventional CMUT probe, the disposable snCMUT patch offers enhanced contrast and the ability to image deeper regions, thanks to its high transmission efficiency. Data are presented as means ± standard deviation ( n = 4 independent experiments). All values are expressed in a.u., which denotes arbitrary units.

Article Snippet: Transducers were vertically placed on the surface of the phantom using ultrasound gel and operated using a commercial ultrasound imaging system (Vantage 256 system, Verasonics, Inc.) to scan over the phantom and reconstruct the imaging planes by employing a plane-wave compounding method, custom-programmed by MATLAB (MathWorks).

Techniques: Ultrasound Gel, Imaging, Standard Deviation, Transmission Assay

Journal: Nature Communications

Article Title: Silicon nanocolumn-based disposable and flexible ultrasound patches

doi: 10.1038/s41467-025-61903-x

Figure Lengend Snippet: a Photograph of attached disposable snCMUT patches onto both sides of the human neck for real-time ultrasound imaging and blood pressure monitoring of human carotid arteries. The B-mode images at the human neck surface aligned with vertical cross-sections of the common carotid artery (CCA) on the right ( b ) and left ( c ) side of the neck. The enhanced transmission efficiency provided clear ultrasound images, enabling the distinction of not only the CCA but also the internal jugular vein (JV) and sternocleidomastoid muscle (SCM). d The B-mode image of left neck side transverse CCA for monitoring carotid artery pulsations from detecting wall. The applied DC bias voltage was 30 V supplemented by 24.5 V PP of 4.25 MHz AC wave for ultrasound imaging via disposable snCMUT patches. e M-mode image of the pulsation pattern of CCA walls. f The waveforms of blood pressure derived from carotid vessel diameters of the M-mode image ( e ) as a function of time. Physiological parameters from the arterial pulse waveforms, including the heart rate and blood pressure, were derived. g Systolic blood pressure on the left and right side of the neck of 9 healthy volunteers simultaneously monitored by two disposable snCMUT patches. Data are presented as means ± standard deviation ( n = 5 independent experiments).

Article Snippet: Transducers were vertically placed on the surface of the phantom using ultrasound gel and operated using a commercial ultrasound imaging system (Vantage 256 system, Verasonics, Inc.) to scan over the phantom and reconstruct the imaging planes by employing a plane-wave compounding method, custom-programmed by MATLAB (MathWorks).

Techniques: Imaging, Transmission Assay, Derivative Assay, Standard Deviation

Journal: Advanced Science

Article Title: Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

doi: 10.1002/advs.202414306

Figure Lengend Snippet: Schematic representation of label‐free 3D PAUL imaging. a) Illustration of kidney imaging with mechanical‐scanning based dual modal photoacoustic (PA) and ultrasound (US) imaging. The central frequency of the diagnostic transducer is 15 MHz. The laser fluence is under 20 mJ cm −2 . b) During data acquisition, ultrafast ultrasound imaging and multi‐wavelength PA imaging are recorded alternatively at each position. For each position, US images with 5 s acquisition were collected at frame rate of 500 Hz. Multiwavelength PA images (MvPA, 750 and 850 nm) with 1 s acquisition were collected at frame rate of 10 Hz. c) Schematic of PA and label‐free UL acquisition. d) Flowchart of dual modal photoacoustic and ultrasound imaging postprocessing. Clutter filtering was applied to extract blood signal and label‐free super‐resolution ultrasound image was generated by localizing erythrocytes within blood signals. Functional photoacoustic information was extracted by spectrum unmixing of MwPA images. e) Mechanical scanning was conduct to collect 3D kidney structural and physiological information. f) One representative whole kidney microvasculature and oxygenation map of a mouse. g) Quantitative analysis of kidney volume, kidney vasculature and kidney oxygenation from 3D dual modal photoacoustic and ultrasound image. ILAV, interlobular artery‐vein; RAV, renal artery‐vein; IAV, interlobar artery‐vein; and AAV, arcuate artery‐vein.

Article Snippet: The dual‐modal PAUL system consisted of a Verasonics ultrasound imaging research system (Vantage 256, Verasonics Inc., Kirkland, WA, USA), a 15 MHz customized linear array Vermon), and a wavelength tunable (690–950 nm) OPO laser source with 7‐ns‐pulse and 10 Hz pulse repletion rate (Phocus Essential, Opotek, Inc., Carlsbad, CA, USA).

Techniques: Imaging, Diagnostic Assay, Generated, Functional Assay

Journal: Advanced Science

Article Title: Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

doi: 10.1002/advs.202414306

Figure Lengend Snippet: Characterization of label‐free PAUL imaging. a) An ultrasound B‐mode image of a mouse kidney. The boundary of the kidney is indicated by the white dash curve. b) A power Doppler image of a mouse kidney. c) A label‐free super‐resolution ultrasound image of a mouse kidney. (d) Zoom‐in vasculature region from (b) and (c). e) 1D vessel profile of the label‐free UL and power Doppler image at line 1 and line 2 indicated in (b) and (c). f) PA images of a mouse kidney collected at 750 and 850 nm, respectively. g) The difference PA image. h) Comparison of PA signal at 750and 850 nm. The error bars are standard deviations (N = 3). Unpaired student t ‐test is used. i) Hemoglobin (Hb) and oxyhemoglobin (HbO2) concentration distribution in a mouse kidney. The information was extracted from multiwavelength PA images (750 and 850 nm) via spectrum unmixing. j) Oxygenation saturation (SO2) map of a mouse kidney. k) Comparison of HbO2 and Hb concentration. The error bars are standard deviations (N = 3). Unpaired student t ‐test is used. **** p < 0.0001.

Article Snippet: The dual‐modal PAUL system consisted of a Verasonics ultrasound imaging research system (Vantage 256, Verasonics Inc., Kirkland, WA, USA), a 15 MHz customized linear array Vermon), and a wavelength tunable (690–950 nm) OPO laser source with 7‐ns‐pulse and 10 Hz pulse repletion rate (Phocus Essential, Opotek, Inc., Carlsbad, CA, USA).

Techniques: Imaging, Comparison, Concentration Assay